EZ-Gel PRF vs PRP vs PRFM: Understanding the Differences in Regenerative Aesthetics

When it comes to regenerative aesthetics, it can feel overwhelming to sort through all the acronyms and options. You may have heard of platelet-rich plasma (PRP) for hair growth, platelet-rich fibrin matrix (PRFM) for rejuvenation, or the newer EZ-Gel PRF as a natural alternative to fillers. While they all sound similar, each treatment has unique benefits, applications, and results. If you’ve ever wondered which one might be right for you, you’re in the right place. Read on as we break down the differences among PRP, PRGM, and EZ-Gel PRF and answer all of your questions.

What is the difference between PRP, PRFM, and EZ-Gel PRF?

PRP, PRFM, and EZ-Gel PRF all use components from your own blood to stimulate healing and regeneration, but the way they are processed and used sets them apart.

PRP (platelet-rich plasma) is created by drawing blood and spinning it in a centrifuge to separate out platelets, growth factors, and plasma. This golden fluid is then injected into areas like the scalp for hair growth or the skin for rejuvenation.

PRFM, or platelet-rich fibrin matrix, takes PRP a step further. It is processed differently to form a fibrin scaffold that allows for a slower release of growth factors. Think of it as PRP with more structure and staying power (aka longer-lasting results).

EZ-Gel PRF is an advanced form of PRF (platelet-rich fibrin). Blood is spun at lower speeds to preserve more platelets, stem cells, and white blood cells. It is then gently heated and cooled, transforming it into a smooth gel consistency that resembles dermal filler. Unlike synthetic fillers, it is 100% natural and derived from the patient’s own blood.

Which is better: PRP, PRFM, or EZ-Gel PRF?

The answer depends on the individual’s goals. PRP is the most established treatment for hair restoration and is also used for more mild skin rejuvenation, especially when paired with microneedling (aka Vampire Facial). PRFM tends to last longer and is often preferred for deeper facial rejuvenation, especially for delicate areas like the under-eyes. EZ-Gel PRF is best for patients who want filler-like volume but prefer an all-natural option. AEDIT founder Dr. William Kennedy explains, “it’s not about which one is better, it’s about which one is best suited for the individual.” “Each has its own advantages depending on where and how it’s used.”

Which treatment lasts longer: PRP, PRFM, or EZ-Gel PRF?

EZ-Gel PRF typically lasts the longest. When used for facial rejuvenation or under-eye volume, most patients see results for 12 to 18 months. PRFM generally lasts around nine to 12 months and PRP tends to be the shortest-lasting, usually between three and six months.

Does EZ-Gel PRF give better results than PRP?

When it comes to volume loss and skin texture, EZ-Gel PRF usually outperforms PRP. Because it’s processed into a gel-like consistency and contains a higher concentration of platelets and regenerative cells, it not only smooths and improves skin quality but also adds subtle, natural-looking volume in areas like the under-eyes and cheeks.

PRP, on the other hand, remains the gold standard for hair restoration. Its liquid form makes it ideal for evenly spreading across the scalp to stimulate dormant follicles and improve hair density. In other words, EZ-Gel PRF is often the better option for rejuvenating and volumizing the face, while PRP continues to shine for promoting hair growth.

Is PRFM more effective than PRP?

PRFM isn’t necessarily better, but it can be more effective than PRP in certain areas. “PRFM works a little differently from standard PRP,” says Dr. Kennedy “Its fibrin matrix gives it more structure and allows for a gradual release of growth factors, which helps promote smoother, more consistent results. It’s a great option for patients who want subtle rejuvenation in delicate areas, like under the eyes, to achieve longer lasting effects.” PRP, on the other hand, is the go-to treatment for scalp injections, since its liquid form spreads more easily to stimulate hair follicles and improve density.

How natural are the results with EZ-Gel PRF compared to fillers?

One of the biggest advantages of EZ-Gel PRF is that it offers natural-looking results. Since it’s made entirely from the patient’s blood, it integrates seamlessly into the tissues without the risk of allergic reactions or overfilled appearances. While traditional fillers can sometimes look puffy or unnatural if overdone, EZ-Gel PRF provides subtle volume and improves skin quality at the same time.

Is EZ-Gel PRF safe?

Yes, EZ-Gel PRF is very safe because it’s made entirely from your own blood. It contains no additives or chemicals—the gel is formed simply by spinning, heating, and cooling your plasma. This makes it 100% natural, with limited risk of allergic reactions or foreign-body complications. Aside from temporary swelling or bruising at the injection site, serious side effects are extremely rare.

Are PRP and PRFM treatments FDA-approved?

PRP and PRFM are not FDA-approved specifically for cosmetic treatments. However, they are generally considered safe since they use the individual’s own blood, and the devices used to prepare them are FDA-cleared.

Which is best for hair restoration: PRP, PRFM, or EZ-Gel PRF?

PRP is still the most popular option for hair restoration, but PRFM can be used when someone wants longer-lasting results or when a provider prefers the fibrin scaffold to help “hold” growth factors at the injection site. Since EZ-Gel PRF has a gel-like consistency, it is not suited for the scalp.

Can PRFM or EZ-Gel PRF replace dermal fillers?

In certain areas, yes. EZ-Gel PRF is especially popular under the eyes because it provides subtle, natural volume without the puffiness or bluish tint that sometimes occurs with synthetic fillers. PRFM, on the other hand, works well for general facial rejuvenation and soft tissue improvement since its fibrin matrix helps smooth and strengthen the skin over time. While neither option can fully replace traditional fillers, both offer natural-looking enhancements for patients who want subtle improvements without synthetic products. Dr. Kennedy reminds us, “dermal fillers are still the go-to when a patient wants immediate, more pronounced volume or contouring.” “While PRFM and EZ-Gel PRF can improve skin quality and provide subtle, natural fullness over time, hyaluronic acid fillers deliver instant structure and lift especially in areas like the cheeks, jawline, or lips.”

Which treatment works best for skin rejuvenation?

All three treatments can rejuvenate the skin, but EZ-Gel PRF and PRFM tend to provide more noticeable and longer-lasting results than PRP. That being said, PRP is better suited for those who want subtle and gradual results while PRFM and EZ-Gel PRF are better for those looking for more structural support or volume. “For example, for someone in their 30s who’s starting to notice mild skin dullness or fine lines might do best with PRP,” shares Dr. Kennedy “It delivers a subtle, natural glow and gradual collagen boost. But for patients who’ve begun to lose volume, say, under the eyes or in the cheeks then PRFM or EZ-Gel PRF can provide more structure and support for longer-lasting rejuvenation.”

How much does EZ-Gel PRF cost compared to PRP or PRFM?

While prices vary depending on location and provider, PRP is generally the most affordable. A single PRP session can range from $500 to $1,500 while PRFM typically falls between $800 and $2,000 per treatment. EZ-Gel PRF tends to be the highest-priced, often ranging from $1,200 to $2,500 per session. While EZ-Gel PRF is the most expensive upfront, it can sometimes be the more cost-effective option because it has longer-lasting results.

Is EZ-Gel PRF widely available?

EZ-Gel PRF is relatively new compared to PRP and PRFM, so it’s not widely available. However, its popularity is growing quickly as more providers recognize its benefits as a natural filler alternative.

How many sessions are needed for PRP vs PRFM vs EZ-Gel PRF?

For PRP skin rejuvenation, most providers recommend a series of three to four sessions spaced about four to six weeks apart, followed by maintenance once or twice a year. For PRP hair restoration, the protocol is usually more intensive. Patients often start with four to six monthly sessions to stimulate dormant follicles, followed by maintenance every three to six months to keep results.

PRFM generally requires fewer sessions than PRP since its effects last longer—often two to three treatments for skin or under-eyes, with maintenance yearly. EZ-Gel PRF can sometimes deliver noticeable improvement after a single session, especially under the eyes or for subtle volume restoration, though additional treatments may be suggested for optimal, lasting results.

Do EZ-Gel PRF injections hurt more than PRP?

EZ-Gel PRF injections don’t usually hurt more than PRP, though some people notice a slightly fuller sensation during injection because of the gel’s thicker consistency. In both cases, providers often use numbing cream or local anesthesia. Recovery is minimal for all three treatments. Most people are back to normal within a day or two with PRP and PRFM while it may take an extra day for EZ-Gel PRF because it can cause a bit more puffiness.

How soon can you see results with EZ-Gel PRF compared to PRP?

PRP results tend to appear gradually over several weeks as your body regenerates tissue and stimulates collagen. PRFM, on the other hand, provides quicker results because of its structural support. EZ-Gel PRF often offers the fastest visible results since the gel adds instant volume while also working long-term to improve skin quality.