Radiesse® by Merz Pharmaceuticals is a commercial injectable formulation of calcium hydroxylapatite (CAHA). Similar to the calcium mineral found in bone, calcium hydroxylapatite is a compound increasing volume and plumpness for both cosmetic and functional purposes.

Radiesse® Overview - Everything You Need to Know

The Skinny

avg. recovery
5 days
$650 - $1598

About the Procedure

Last Updated: 09.25.2021

Radiesse® by Merz Pharmaceuticals is a specially formulated injectable dermal filler used to smooth fine lines and wrinkles and also improve volume loss in the backs of the hands. Radiesse® is unique in that its primary ingredient is calcium hydroxylapatite (CAHA), which is formulated as calcium microspheres. CAHA is believed to both enhance skin volume and plumpness and stimulate the body’s production of natural collagen to provide natural looking, lasting results. Radiesse® is approved by the United States Food and Drug Administration (FDA) to treat moderate to severe facial wrinkles, however, it is also used off-label for volume loss in the backs of the hands. Radiesse® is commonly used to treat: - Nasolabial folds (i.e. smile lines) - Marionette lines - Oral commissures (i.e. corners of the mouth) - Pre-jowl fold - Chin wrinkles - Aging hands The active ingredient CAHA of Radiesse® is generally believed to provide a more lasting solution than fillers composed of hyaluronic acid like Juvéderm® and Restylane®. Bellafill® and Sculptra® contain alternative primary ingredients and may provide results more comparable to Radiesse®.

The goal of calcium hydroxylapatite-based fillers is to semi-permanently improve the volume and/or contour of areas on the face and body.


Radiesse® addresses concerns such as:

Recovery Notes

Most individuals experience minimal recovery with swelling, tenderness, and redness at the injection site lasting one to two days. For some, swelling may persist for a few days. Many candidates resume most all activities directly after the injections.

Ideal Candidate

The ideal candidate for a Radiesse® injection is over 18 years old and looking for a safe and effective temporary solution to common facial cosmetic concerns.

Not Recommended For

Radiesse® is not recommended for women who are pregnant or nursing, and anyone with an allergy to the components of Radiesse®.

Side Effects

Common side effects of Radiesse® injections include redness, dryness, and flaking. Firmess, tenderness, itchiness, lumps, bumps, possible site infection, and/or bruising/discoloration may occur. A serious complication of a Radiesse® injection is intravascular injection (injection into a blood vessel) leading to skin necrosis. Severe allergic reactions can occur.


  • Stimulates collagen
  • Minimally invasive
  • Semi-permanent


  • Possible asymmetry
  • Reoccurring expense