Evidence Basedcheckmark

Hyaluronidase is an enzyme that degrades hyaluronic acid-based dermal fillers (like Juvederm®, Belotero®, and Restylane®) to reverse previously performed cosmetic injectable dermal filler procedures.

Hyaluronidase Overview - 1160

The Skinny

Average Recovery

2 days








$100 - $1498

The Specifics

What is hyaluronidase?

Hyaluronidase is an enzyme that specifically breaks down hyaluronic acid. In addition to its popularity as a cosmetic injectable, hyaluronic acid naturally occurs in the body. An injection of hyaluronidase, therefore, may also break down naturally occurring hyaluronic acid and cause allergic reactions.

Hyaluronidase has many cosmetic and medical uses including reversal of a vascular occlusion, alleviating the Tyndall effect (bluish skin discoloration), reversal of an unacceptable cosmetic outcome, and targeted therapy to unwanted nodule formation. Hyaluronidase can be used to break down Juvederm®, Restylane®, and Belotero® amongst other injectable hyaluronic acid-based fillers.

What cosmetic concerns does hyaluronidase treat?

  1. Reversing Agent for Hyaluronic Acid Dermal Fillers: Hyaluronidase is an enzyme used to reverse a previous cosmetic injection of a hyaluronic acid-based filler.
  2. Nodule Formation: Hyaluronidase can also be specifically targeted to breakdown unwanted nodule formation in otherwise desirable cosmetic outcomes utilizing hyaluronic acid-based dermal fillers.

Who is the ideal candidate for a hyaluronidase procedure?

The ideal candidate for a hyaluronidase procedure is an individual looking to reverse an undesirable cosmetic outcome or reduce unwanted nodule formation. The use of hyaluronidase injections is not recommended in individuals who have experienced anaphylaxis to wasp or bee stings, those on certain over-the-counter and prescription medications, and those with an allergy to any component of hyaluronidase.

What is the average recovery associated with a hyaluronidase procedure?

Most patients experience minimal recovery time following an injection of hyaluronidase. Mild swelling, redness, and discomfort at the injection site usually resolve within 10 days. In some cases, there are some minimal limitations on strenuous activity following the procedure.

What are the potential side effects of a hyaluronidase procedure?

Common side effects of a hyaluronidase injection are bruising, swelling, and redness at the injection site. More serious side effects include severe allergic reactions.

What can someone expect from the results of a hyaluronidase procedure?

Results of a hyaluronidase injection are typically immediately visible, however, some individuals may not see results for up to 48 hours. Others may require higher doses of hyaluronidase, if cross-linking has occurred. Results will continue to evolve in all patients over the course of seven to 10 days. Some candidates may not see complete results the first time they receive a hyaluronidase injection and will require multiple injections for desired results.

What is the average cost of a hyaluronidase procedure?

The average cost of a hyaluronidase is $100 to $1,500. The actual cost of the procedure will vary by location, board certified dermatologist or plastic surgeon, and individual candidate needs.


  • Immediate Results
  • Minimally Invasive
  • Short Recovery
  • Non-surgical Revision


  • Multiple Treatments Will Be Required
  • Unpredictable Outcomes

Invasiveness Score


Invasiveness is graded based on factors such as anesthesia practices, incisions, and recovery notes common to this procedure.

What to Expect

Hyaluronidase is a non-surgical injectable used to dissolve previous hyaluronic acid injectables in a minimally invasive, temporary procedure. Here is a quick guide for what to expect before, during, and after a hyaluronidase procedure:

The Takeaway

Hyaluronidase is a specific enzyme that is used for its filler dissolving properties to reverse undesirable cosmetic outcomes or nodule formation in previous hyaluronic acid based dermal filler injections. Hyaluronidase works by degrading the hyaluronic acid component of popular fillers like Juvederm®, Belotero®, and Restylane®. Results typically evolve over the course of seven to 10 days, and multiple treatments may be required for desired results.
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Source List


AEDIT uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

  1. Medline Plus Clinical Application of Earlobe Augmentation with Hyaluronic Acid Filler in the Chinese Population MedlinePlus.gov; 2016-12-28


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