Hyaluronidase is an enzyme that degrades hyaluronic acid-based dermal fillers (like Juvederm®, Belotero®, and Restylane®) to reverse previously performed cosmetic injectable dermal filler procedures.

Hyaluronidase Overview - Everything You Need to Know

The Skinny

avg. recovery
2 days
Is permanent
$100 - $1498

About the Procedure

Last Updated: 09.18.2021

Hyaluronidase is an enzyme that specifically breaks down hyaluronic acid. In addition to its popularity as a cosmetic injectable, hyaluronic acid naturally occurs in the body. An injection of hyaluronidase, therefore, may also break down naturally occurring hyaluronic acid and cause allergic reactions. Hyaluronidase has many cosmetic and medical uses including reversal of a vascular occlusion, alleviating the Tyndall effect (bluish skin discoloration), reversal of an unacceptable cosmetic outcome, and targeted therapy to unwanted nodule formation. Hyaluronidase can be used to break down Juvederm®, Restylane®, and Belotero® amongst other injectable hyaluronic acid-based fillers.

The goal of hyaluronidase is to reverse the unsatisfactory result of previous hyaluronic acid-based filler injections.


Hyaluronidase addresses concerns such as:

Recovery Notes

Most patients experience minimal recovery time following an injection of hyaluronidase. Mild swelling, redness, and discomfort at the injection site usually resolve within 10 days. In some cases, there are some minimal limitations on strenuous activity following the procedure.

Ideal Candidate

The ideal candidate for a hyaluronidase procedure is an individual looking to reverse an undesirable cosmetic outcome or reduce unwanted nodule formation.

Not Recommended For

The use of hyaluronidase injections is not recommended in individuals who have experienced anaphylaxis, those on certain medications, and those with an allergy to any component of hyaluronidase.

Side Effects

Common side effects of a hyaluronidase injection are bruising, swelling, and redness at the injection site. More serious side effects include severe allergic reactions.


  • Immediate results
  • Minimally invasive
  • Short recovery
  • Non-surgical revision


  • Multiple treatments will be required
  • Unpredictable outcomes

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